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KMID : 0880520110470010048
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Chonnam Medical Journal
2011 Volume.47 No. 1 p.48 ~ p.50
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A Case of a False-Positive Anti-Myeloperoxidase Antibody ELISA in a Patient with Hypothyroidism
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Jin Mi-Kyung
Seo Kwan-Yong
Kang Jin-Young
Choi Ji-Young
Yoon Se-Hee
Kim Yong-Lim
Won Dong-Il
Park Sun-Hee
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Abstract
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We present a case of a false-positive anti-myeloperoxidase (MPO) antibody result on an ELISA in a patient with anti-thyroid microsomal antibody (TMA)-positive hypothyroidism. A 41-year-old woman presented with dyspnea on exertion. The initial evaluation revealed pericardial effusion associated with hypothyroidism. In addition, microscopic hematuria with normal renal function and positive cytoplasmic anti-neutrophil cytoplasmic antibodies (c-ANCA) on immunofluorescent assay were found. In further evaluation, elevated anti-TMA and MPO antibodies by ELISA. While no definite signs of vasculitis were present, the clinical state improved with thyroid hormone replacement and diuretics. Anti-MPO antibody was still positive in the follow-up tests, and microscopic hematuria persisted. On the basis of previous reports that thyroid peroxidase and MPO molecules contain cross-reactive epitopes that are exposed in denaturated molecules, we suggest that in a patient with anti-TMA-positive hypothyroidism, anti-MPO antibody might also be positive on ELISA without clinical signs of vasculitis.
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KEYWORD
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Hypothyroidism, Anti-thyroid peroxidase antibodg, Anti-myeloperoxi dase antibody
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